It has been found that octreotide can stimulate NHE8 expression in colonitis mice, and somatostatin receptor 2 (SSTR2) agonist fragments and somatostatin receptor 5 (SSTR5) agonists can inhibit ERK1 / 2 phosphorylation by restoring NHE8 expression [70]. Here, SSTR2 is linked to digestive system cancer.