It has been found that octreotide can stimulate NHE8 expression in colonitis mice, and somatostatin receptor 2 (SSTR2) agonist fragments and somatostatin receptor 5 (SSTR5) agonists can inhibit ERK1 / 2 phosphorylation by restoring NHE8 expression [70]. This evidence concerns the gene MAPK3 and digestive system neoplasm.