CXCR4 and WHIM syndrome: Additionally, WHIM syndrome (Warts, Hypogammaglobulinemia, Infection, and Myelokathexis) is the only known immunological disease directly results from aberrant CXCR4 function, and it has been attributed to a deletion of C-terminal residues of CXCR4 that prevents proper receptor internalization (Diaz and Gulino, 2005).