TRAF6 and neoplasm: MicroRNAs, such as miR-101, miR26b, miR-26a, miR-28-5, and miR-363, were found dramatically downregulated in ENKL compared to normal NK cells. They functioned by regulating the expression of their predicted target genes. MiR-15a was reported to be downregulated by LMP-1. Besides, miR-146a could downregulate NF-κB activity by targeting TRAF6 and function as a tumor suppressor, which sequentially promote cell proliferation and predict poor prognosis.