TOB2 and cancer: Figures 1B,D show ROC plots for the imaged SOX11 and TOB2 peptides, indicating very strong discrimination between benign and cancerous tissue, and Figures 1C,F show box plots of pixel intensity from the images in Figures 1A,D, respectively. Contrasting with the high relative abundance of these markers in cancer tissue (and others shown in Supplementary Figure 1), Figure 1G illustrates an unidentified peptide in the same tissue (m/z 709.393) that is strongly downregulated in cancer vs. benign tissue.