PTEN and nonpapillary renal cell carcinoma: In this study, we analyzed an RNA sequencing (RNA-Seq) dataset of ccRCC and the GDSC database to identify the key pathways and genes associated with the PTEN mutation using bioinformatics analysis approaches, and evaluated the significance in drug selection, expecting to uncover the potential role of the PTEN mutation in serving as a prediction factor for prognosis and individualized treatment options.