AKT1 and neoplasm: The PI3K/AKT signaling pathway is a prototypic survival pathway that plays a crucial role in promoting tumor cell growth and inhibiting apoptosis (Ao, Guan, Wang, & Wang, 2018; Gupta et al., 2007), and is constitutively activated in various cancer cells (Sun, Wang, Liu, & Wang, 2015; Sun, Zhang, et al., 2015).