PPARGC1A and Insulin resistance: During exploring the interactions and functions of SIRT1 and its target proteins in the development of insulin resistance, the reduced expression of SIRT1 and PGC‐1α is observed in pancreatic β cells of Sprague Dawley (SD) rats with insulin resistance induced by high‐glucose and high‐fat diet, while caloric restriction stimulates the expression of SIRT1 and PGC‐1α.