PPARGC1A and Parkinson disease: The inhibition of AMPK can result in the impaired autophagy of islet β cells, thus correspondingly leading to excessive apoptosis (Wu et al., 2013), which is also similar with the attenuation of α‐synuclein level due to the induction of autophagy through SIRT1 activation in the chronic MPTP/P‐induced mouse model with Parkinson's disease during treadmill exercise (Koo & Cho, 2017), and the reduced atrophy of skeletal muscle in D‐gal‐induced aging rats during ampelopsin‐induced autophagy through activating AMPK/SIRT1/PGC‐1α signaling cascade (Kou et al., 2017).