Importantly, inhibition of EGFR severely reduced the activation of both ERK1/2 and AKT signaling pathways in HEMC-SS chondrosarcoma but not in SW1353 cells (Figure 3B), indicating that activation of ERK1/2 and AKT signaling in HEMC-SS chondrosarcoma cells depends on EGFR activation, whereas it is not the case in SW1353. This evidence concerns the gene MAPK3 and chondrosarcoma.