Given that constitutive activation of EGFR is high in HEMC-SS chondrosarcoma cells compared to SW1353 cells, while protein express level of the receptor is similar in both cells, we hypothesized that constitutive activation of the receptor in HEMC-SS chondrosarcoma cells may be due to an EGF/EGFR autocrine loop. Here, EGFR is linked to chondrosarcoma.