Recently, however, several studies combining state-of-the-art molecular profiling with detailed clinical annotation of large patient cohorts with long clinical follow-up identified two key molecular risk factors in ALK+ NSCLC: EML4-ALK fusion variant 3 (E6;A20) [11-16] and the presence of TP53 mutations [17-19]. Here, TP53 is linked to non-small cell lung carcinoma.