Interestingly, in keeping with the finding of earlier and broader metastatic dissemination, the presence of V3 is also associated with a worse performance status of newly diagnosed ALK+ NSCLC patients (Figure 1B), which has already been recognized as a clinical risk factor in ALK+ disease [2], but is itself neither biologically insightful nor druggable. This evidence concerns the gene ALK and non-small cell lung carcinoma.