EGFR activation (EGFR phosphorylation at Tyr 1173) is found in lungs, and bronchiolar epithelial cells of house dust mite (HDM) induced asthma mice, while its inhibition can reduce AHR, airway smooth muscle cell thickening and goblet cell metaplasia during HDM treatment, suggesting EGFR in airway epithelium plays an essential role in mediating AHR and lung remodeling in a chronic allergic asthma model [41]. The gene discussed is EGFR; the disease is asthma.