A decrease in the intensity of mitochondrial biogenesis due to impaired Nrf2 translocation to the nucleus was observed in the gentamycin-induced nephrotoxicity (Negrette-Guzmán et al., 2015), hypertonia caused by injection of low doses of lipopolysaccharide (Wu K.L.H. et al., 2016), multiple sclerosis (Hayashi et al., 2017), and in placentas of women suffering from diabetes combined with obesity (Duan et al., 2018). This evidence concerns the gene NFE2L2 and multiple sclerosis.