Dimethyl fumarate (Lastres-Becker et al., 2016) and the CCCP (carbonyl cyanide m-chlorophenylhydrazone) (Ivankovic et al., 2016) support p62/SQSTM1-dependent mitophagy by activating Nrf2 and contribute to Parkinson’s disease therapy. Here, NFE2L2 is linked to Parkinson disease.