Myeloma subtype-specific associations of germline risk variants and somatic changes in the tumor genome have been reported; e.g., the association of a variant at CCND1 with t(11;14)+ myeloma, or of a variant at CBX7 with myeloma not harboring chromosomal translocation (see section Racial and Ethnic Factors). The gene discussed is CCND1; the disease is plasma cell myeloma.