MYC and plasma cell myeloma: MYC is among the most consistently upregulated genes in new myeloma (Zhan et al., 2006) and its overexpression frequently becomes “hard wired” in the course of tumor progression due to illegitimate genetic rearrangements such as complex chromosomal translocations and indels at the MYC locus (Bergsagel et al., 1996; Affer et al., 2014).