A recent large-scale WGS analysis of newly diagnosed myeloma (NDMM) by Walker et al. (2018b) – supplemented with RNA-seq data and associated with the clinical and outcome results in nearly 1,300 patients – greatly expanded the list of putative myeloma oncogenes (PTPN11, PRKD2, SF3B1, IDH1, and IDH2) and tumor suppressor genes (UBR5, HUWE1). The gene discussed is HUWE1; the disease is plasma cell myeloma.