Furthermore, miR-155 in PBMCs of systemic lupus erythematosus patients was specifically upregulated by high-mobility group box 1 protein in a MyD88-dependent manner during induction of anti-double-stranded DNA antibody, which is the central pathogenic autoantibody involved in pathogenesis of systemic lupus erythematosus (82). Here, MYD88 is linked to systemic lupus erythematosus.