IGHE and systemic lupus erythematosus: Another recent study found that phagocytosis of anti-dsDNA IgE antibodies (found to be increased in some SLE patients) via the high-affinity FcεRI receptor for IgE, mediates TLR9-mediated sensing of self-DNA in the phagosomes and potentiates IFN production by plasmacytoid dendritic cells (52).