The discovery that the RNA-editing enzyme ADAR1 primarily edits Alu transcripts in humans (155) and that the LINE-1 encoded RT has catalyzed the reverse transcription and genomic insertion of over a million copies of the Alu element in our genome, as well as the co-localization of LINE1 proteins with Ro and La, hints at a central, but still enigmatic, role of this RNA biology in SLE pathogenesis. Here, CALR is linked to systemic lupus erythematosus.