TBXT and graft versus host disease: By targeting Th1 and Th17 specific transcription factors, T-box transcription factor TBX21 (T-bet) and Retinoic acid- related orphan receptor gamma (RORγt), respectively, it was observed that both Th1 and Th17 subsets contribute to GVHD development; yet either lineage alone is sufficient to induce GVHD (14, 15).