Though chemerin does not seem to directly recruit CD8+ T cells via CMKLR1 interactions in this model, there is compelling evidence in the literature to suggest that NK cells mediate various functions that enhance CD8+ T cell cytolytic activity; for example, NK cells have been shown to moderate CD8+ T cell priming during influenza A viral infection and activate CD8+ T cell anti-tumor activity in the YAC-1 mouse lymphoma model (57, 58). Here, CMKLR1 is linked to neoplasm.