RARRES2 and melanoma: While we and others have reported on several tumor types where chemerin/RARRES2 is significantly down-regulated compared to normal tissue counterparts (e.g., melanoma, lung, prostate, liver, adrenal, etc.)(20–25), chemerin/RARRES2 has been shown to be up-regulated in fewer tumor types (e.g., mesothelioma, squamous oral cancers) (26–28).