CD80 and diabetes mellitus: Several other mouse models have been employed, albeit less frequently, such as the NOD-SCID model of adoptive cotransfer of diabetes (51), the NOD RIP-IFN-β mouse (44), the LCMV-RIP induced model (52), or humanized HLA-DQ8/RIP-B7.1 or HLA-DR4 mice (39, 46).