The first category of tumors with recurrent genetic mutations are those that arise due to familial syndromes (Table 2) which include McCune-Albright syndrome, multiple endocrine neoplasia types 1 and 4 (MEN1 and MEN4), familial isolated pituitary adenomas (FIPA), and Carney complex (28). This evidence concerns the gene MEN1 and familial isolated pituitary adenoma.