We selected as a model the primary SW480 colon carcinoma cell line and its derivative metastatic SW620 cell line which express a truncated version of APC, have constitutively active Wnt signaling and are prototype of KRAS-driven colon cancer cells in comparison with the non-malignant colon cell line 112CoN (Figure 1). Here, APC is linked to malignant colon neoplasm.