Results indicated that voltage-gated ion channel activity genes played an important role in epilepsy with ASD patients, including SCN1A, SCN2A, CACNA1A, CACNA1H, CACNA1D, and KCNQ2 (P < 0.05), which were as further classified as sodium ion channel genes, calcium ion channel genes, and potassium ion channel genes (detailed information in Table S2). This evidence concerns the gene SCN2A and epilepsy.