Results indicated that voltage-gated ion channel activity genes played an important role in epilepsy with ASD patients, including SCN1A, SCN2A, CACNA1A, CACNA1H, CACNA1D, and KCNQ2 (P < 0.05), which were as further classified as sodium ion channel genes, calcium ion channel genes, and potassium ion channel genes (detailed information in Table S2). Here, CACNA1D is linked to epilepsy.