TARDBP and amyotrophic lateral sclerosis: Even if most ALS cases are sporadic, the pathways disrupted in familial cases may also be affected in sporadic cases, as both sALS and fALS can share common molecular signatures or functional biological effects such as FUS or TDP43 protein aggregations or accumulation of stress granules formation (45), disruption in RNA processing (46), or disruption of autophagy and mitochondrial functions (47).