Figure 3C shows differential time-course changes in oxy-Hb levels between groups for a representative channel, ch38, in the left frontopolar region. We found no significant differences between the BD subjects with (n = 4) and without (n = 20) medication (Supplementary Table 3) and between the MDD subjects with (n = 11) and without (n = 32) medication (Supplementary Table 4). This evidence concerns the gene GSTM1 and major depressive disorder.