Hepatic steatosis, obesity, hypertriglyceridaemia, increased absorbing lipids throughout the day. The levels of plasma triglyceride are high all times. Other aberrant expressions of metabolism-regulating genes have also been observed, including FABP1, ACS4, HMGCR, LDLr. The gene discussed is ACSL4; the disease is obesity due to melanocortin 4 receptor deficiency.