Only recently, Antaris et al. described the synthesis of the biocompatible and renally cleared NIR-II organic fluorophore CH1055 (Figure 1A) and its use for targeted tumor imaging after conjugation with an anti-Epidermal Growth Factor Receptor (EGFR) affibody-molecule (Antaris et al., 2016). The gene discussed is EGFR; the disease is neoplasm.