MTOR and Dravet syndrome: Trisomic cells from DS or DS mouse models exhibit mitochondrial dysfunction, increased oxidative stress and damage, and mTOR pathway hyperactivation leading to reduced autophagy (Busciglio et al., 2002; Helguera et al., 2013; Cenini et al., 2014; Perluigi et al., 2014; Tramutola et al., 2015, 2016; Liu et al., 2017).