In addition, long-range, PV- and SOM-mediated inhibitory cortical inputs to striatal SPNs were described recently (Rock et al., 2016; Melzer et al., 2017) and other types of striatal interneurons (e.g., TH- and calretinin-expressing interneurons) could potentially contribute to aberrant GABAergic synaptic activity in HD. Here, TH is linked to Huntington disease.