MTOR and Other metabolic disease: Disruption of MTOR signaling has been documented in numerous pathological conditions, including cancer, neurological disorder, and metabolic disorder (Lipton and Sahin, 2014; Saxton and Sabatini, 2017) Polycystic kidney disease (PKD) patients with inherited mutations in ciliary genes show deregulation of the MTOR signaling pathway (Shillingford et al., 2006; Wahl et al., 2006).