This meta-analysis of 18 retrospective cohort studies including 15 articles covering PD-L1 and six studies concerning PD-1, a total of 1836 patients, comparing different expression level of PD-L1/PD-1 and the prognosis of NPC showed that no statistical significance was found between higher/positive expression of PD-L1/PD-1 and the prognosis of NPC. The gene discussed is CD274; the disease is nasopharyngeal carcinoma.