8 Cheng Cheng XW XW ,  Kuzuya Kuzuya M M ,  Kim Kim W W ,  et al et al Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase/Akt-dependent hypoxia-induced factor-1 alpha reactivation in mice of advanced age Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase/Akt-dependent hypoxia-induced factor-1 alpha reactivation in mice of advanced age . The gene discussed is AKT1; the disease is ischemia.