VEGFA and neoplasm: The formation of ascites involves increased peritoneal microvasculature, endothelial cell permeability, invasion and metastasis of tumor cells, and the anoxic environment of the peritoneal cavity, which are associated with VEGF-A.(17–20) Therefore, we tested whether the ketogenic diet affected the production of VEGF-A, which is involved in the accumulation of ascites.(21) Mice in the ketogenic diet group showed a significant decrease in serum and ascites VEGF-A levels compared with the regular diet group (Fig. 4A and B).