A diet that produces higher blood glucose would increase the risk of T2DM,(8,9) and even glycemic index (the area under the glycemic curve during a 2 h after consumption of 50 g of carbohydrate) was introduced to assess a potential role of diets in the development of T2DM.(8) Two main mechanisms also have been hypothesized, one is the increase in insulin resistance, and the other is pancreatic exhaustion resulting from the increased demand of insulin.(8) However, it is not clear how glucose as dietary source increases the risk of T2DM. The gene discussed is INS; the disease is Insulin resistance.