TNFAIP3 and autoimmune hepatitis: Since DRB1 and TNFAIP3 were distantly located on the different arms of chromosome 6 (DRB1: 6p21.32, 32578769–32589848 in GRCh38, TNFAIP3: 6q23.3, 137867188–137883312), linkage disequilibrium was not strong between these two loci (r2 = 0.003, between the DRB1 risk alleles and deleterious variants in TNFAIP3 in AIH patients), suggesting that deleterious variants in TNFAIP3 and the DRB1 risk alleles would be independently associated with AIH.