Since SORLA, an important sorting protein in neuronal cells and adipocytes, is expressed in HER2-positive cancer cells (Fig. 1a), we were interested to re-examine the subcellular localization of endogenous HER2 in breast cancer cells with variable levels of SORLA expression (Fig. 1a, c; Supplementary Fig. 1d). The gene discussed is SORL1; the disease is breast cancer.