Male Malt1fl/fl;FIC or female Malt1fl/fl;FIC/FIC mice develop a lethal auto-inflammatory syndrome with a massive pathological activation of Tconv and B cells (Supplementary Fig. 5a-f) with the same kinetics and severity compared to Bcl10fl/fl;FIC mice (Fig. 1a–g) or FoxP3-deficient scurfy mice2. The gene discussed is FOXP3; the disease is autoinflammatory syndrome.