We found that in ccRCC, the endogenous ligand synthesis genes CYP11A and CH25H were expressed at low levels and that the decomposition (oxysterol) enzyme HSD3B7 had a nearly 10-fold higher expression in ccRCC than in adjacent tissue (Fig. 6d, i). This evidence concerns the gene CYP11A1 and nonpapillary renal cell carcinoma.