TP53 and head and neck squamous cell carcinoma: Similarly, studies have reported that the induction of cell cycle arrest may effectively control tumour cell proliferation34, treatment with resveratrol may induce cell cycle arrest at the S phase through activation of Cdc2 expression in human ovarian OVCAR-3 cells35 and pactamycin analogues may induce S-phase arrest and consequently suppress the proliferation of HNSCC cells through the p53-dependent pathway36.