While it has been reported that CLQ has a unique p53-modulating activity and it increases p53 protein expression in human T-cell leukemia MOLT-4 cells, p53 protein levels were modestly regulated upon CLQ treatment in our study (Supplementary Fig. 6a), suggesting that other molecular targets mediate antimelanoma effects of CLQ. The gene discussed is TP53; the disease is T-cell leukemia.