Therefore, we proposed that ZCCHC10 play a tumor-suppressive role through stabilizing p53 protein: ZCCHC10 interacts with p53 and suppresses MDM2-mediated ubiquitination of p53 through disrupting the interaction between p53 and MDM2, leading to stability and accumulation of p53; once accumulated, p53 prevents oncogenic process by directly or indirectly regulating a series of genes involved in cell cycle (p21), apoptosis (Bax, Bcl2, Caspase 3) and EMT (CDH1, Snail, Slug) (Fig. 8). This evidence concerns the gene MDM2 and neoplasm.