S100A8 and gastric adenocarcinoma: Ohnishi et al. demonstrated that transgenic mice overexpressing CagA alone develop significant gastric epithelial cell hyperproliferation and gastric adenocarcinoma (2); our studies have now demonstrated that in addition to the role of CagA facilitating H. pylori-induced injury, it also plays a major role in H. pylori-induced gastric dysbiosis.