Although EPCR binding appears to be an ancient parasite adhesion trait that has been retained within the PfEMP1 family across the large time span that separates human and chimpanzee malaria species (9, 49), and several studies have converged toward its importance for parasite cytoadhesion (10, 13, 14, 26, 35, 36), it recently has been questioned whether EPCR is a physiological endothelial receptor for P. falciparum (40). The gene discussed is PROCR; the disease is malaria.