The TCGA molecular subtypes had the most variation across the different subtypes for the BCR diversity measurements (IGHG Shannon entropy, q = 1 × 10− 14, IGHG Gini-Simpson, q = 4 × 10− 9 by ANOVA after Benjamini-Hochberg multiple testing correction), indicating that tumor gene expression differences were associated with variation in B cell diversity (Fig. 2b, c). The gene discussed is BCR; the disease is neoplasm.