Moreover, increased TIM-1 expression is also found in certain human cancer tissues, such as gastric cancer, clear renal cell carcinoma, LCS, primary central nervous system lymphoma, colorectal cancer and so on, and the expression level of TIM-1 in cancer tissues or cancer cells is significantly correlated with cancer progression and survival of the patients [19–21, 29, 30]. This evidence concerns the gene HAVCR1 and Langerhans cell sarcoma.