In our present study, we firstly found that the TIM-1 expression was increased in NSCLC tissues compared with the adjacent normal tissues, and the OS rate of lung cancer patients (both adenocarcinoma and squamous cell carcinoma) with higher TIM-1 expression was significantly lower compared with the patients with lower TIM-1 expression. The gene discussed is HAVCR1; the disease is non-small cell lung carcinoma.