Fu et al. found that the combination of PCT (cut-off 8.06 ng/ml), CRP (cut-off value 116 mg/l), and IL-6 (cut-off 186.5 pg/ml) increased the sensitivity and specificity for early diagnosis of candidemia (n = 23) and its distinction from Gram-positive/negative bacteremia (AUC to 0.912) in 85 ICU septic patients [27]. This evidence concerns the gene IL6 and bacterial infectious disease with sepsis.