These findings show that globally increasing β2-adrenergic receptor stimulation with clenbuterol treatment dampens stroke-induced expression of both pro- and anti-inflammatory mediators in the post-stroke brain, whereas selective knockout of Adrb2 from Cx3cr1-lineage cells is sufficient to increase post-stroke expression of both pro- and anti-inflammatory genes. This evidence concerns the gene ADRB2 and stroke disorder.