Intriguingly, recent reports indicate that in HeLa cells Rab5c selectively regulates cell motility and cytoskeletal dynamics and that Rab5c operates semi-independently from the other isoforms by promoting AMAP1-PRKD2 complex formation to enhance a growth factor-stimulated β1 integrin recycling pathway that regulates cancer cell invasion [54, 55]. Here, PRKD2 is linked to cancer.