INS and diabetes mellitus: After further division of the patients with DM, the survival of orally treated patients was 84.5% (60 events), while that for insulin-treated patients was 75.7% (67 events), suggesting a statistically significant difference between the last group of patients and both the patients without diabetes (p = 0.003) as well as the orally treated patients (p < 0.001, Fig. 1a, b).