Following the same analysis pattern, the survival of orally treated patients was 64.9% (136 events) and 56.9% for insulin-treated patients (157 events), suggesting a statistically significant difference between the last patients and both the patients without DM (p < 0.001) as well as the orally treated patients (p = 0.014, Fig. 1a, b). Here, INS is linked to diabetes mellitus.