These findings are also in agreement with those provided from a recent meta-analysis, which identified insulin-treated DM as an independent predictor for poor medium- to long-term outcomes, but was not associated with a higher 30-day mortality [37], while another meta-analysis by Sun et al. [38] suggested that DM was not associated neither with increased risk of periprocedural complications nor with lower survival rate at 30 days and 1 year. This evidence concerns the gene INS and diabetes mellitus.