There was no statistically significant difference in the procedural characteristics between patients without DM and those with orally treated and insulin-treated DM concerning the use of balloon or self-expandable valves (77.8% vs 79.7% vs 72.1%, p = 0.126 for the balloon expandable valves) and access route (64.8% vs 64.9% vs 63.0%, p = 0.844 for the transfemoral access). The gene discussed is INS; the disease is diabetes mellitus.