TP53 and cancer: To completely understand the function of miRNAs and mRNAs in radioresistant NPC, we performed pathway enrichment analysis of DEGs and DEMs, the result demonstrated that 4 pathways are considered as the key pathways for the radiosensitivity of NPC, including TGF-beta signaling pathway, Hepatitis B, Pathways in cancer and p53 signaling pathway, which were regulated by miRNA and mRNA together.