CCN2 and hypertensive disorder: According to the inference, genistein binds to the FGF1 protein in fibroblasts of the skin; the FGF1 protein activates the FGFR1 protein in the muscle cells of the heart; FGFR1 protein activates the UBC protein; the UBC protein activates the CTGF protein, and CTGF affects hypertension (Fig. 3c).