ERBB2 and neoplasm: Common SCNAs identified in CIN tumours in these landmark sequencing studies include amplifications of chromosomal regions harbouring genes encoding for receptor tyrosine kinases, or their ligands such as ERBB2, EGFR, and VEGFA, as well as those involved pathways regulating proliferation (MYC) and cell cycle (CCNE1, CCND1, and CDK6).