IFNG and systemic lupus erythematosus: Food restriction and/or calorie restriction have long been known to be beneficial in reducing disease manifestations in lupus-prone mice [38,39], including a lowered atherogenic risk, through mechanisms that include a reduced expression of IL-12 and IFN-γ, reduced NF-κB activation [38,40], and the induction of immunosuppressive CD4+ Tregs [39].